Seven genes may play a role in psoriasis, study suggests.
(1/26) reports, "Scientists in the United States have pointed the finger at seven genes that appear to play a role in psoriasis," according to a study published online in the journal
Nature Genetics
. James Elder, professor of dermatology, University of Michigan, and colleagues, "cast a net through the genetic codes of 1,409 people with psoriasis and 1,436 healthy counterparts of European ancestry, looking for telltale variations in key genes." The researchers "then expanded the study to look at 21 of the most interesting DNA 'hotspots' among an additional 5,048 cases of psoriasis and 5,041 'controls.' Variations in at least seven genes point to the risk of an uncontrolled immune response that leads to psoriasis," the researchers said.
"No single gene or gene variation is responsible for the disease,"
"No single gene or gene variation is responsible for the disease,"
(1/26) adds, "instead, scientists believe that a number of variations, working in concert, perhaps in combination with a triggering factor such as illness, could produce the condition." Patients "with a family history of psoriasis are much more prone to developing it themselves, and the genetic 'hotspots' identified by these research teams could eventually lead to ways to work out who is most likely to do this."
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